© 2015 Cardiff Scientific Society


Welsh School of Pharmacy, Cardiff University      

In this presentation Professor McGuigan will describe, with examples, the role of

‘chance’ (or serendipity) in drug discovery. Examples will be drawn from anti-bacterials

and anti-cancer agents and from his own work in antivirals. In the latter case, the accidental

discovery in Cardiff of a highly potent inhibitor of VZV, the chickenpox/shingles virus, will be described. The agent was in Phase 2 clinical trials in March 2010 and these should be completed by the date of this presentation.

Despite great advances in computation and rational drug design, serendipity continues to play a valuable role in drug discovery.

Drug Discovery: Stumbling and Sometimes Finding. The Story of Cf1743; the Most Potent Antiviral Drug Reported to Date.

Professor Chris McGuigan BSc PhD

Welsh School of Pharmacy, Cardiff University, Cardiff  University

12 th January 2011

Large Chemistry Lecture Theatre