© 2015 Cardiff Scientific Society

Abstract


The number of people with Alzheimer's disease will double in the next generation rising to over one million sufferers in the UK alone.  Identifying genes which contribute to Alzheimer's disease development has already improved our understanding of the disease, but we still do not know what triggers the most common form of Alzheimer's disease, which occurs after the age of 65.  In the last two years new technological advances now allow us to test  every gene in the human genome as a risk factor for Alzheimer's disease. I will present new data describing several new susceptibility genes and gene pathways which trigger disease, discovered from the largest genome-wide association study currently undertaken involving over 16,000 individuals. I will set these findings in the context of lifestyle factors which may also influence our susceptibility to disease, such as smoking, obesity and alcohol use. These discoveries are already providing us with new clues about how the disease starts and more importantly how we can modify or even prevent it in the future.


3rd February 2010 Large Chemistry Lecture Theatre, Cardiff University

The Genetics underlying late-onset Alzheimer’s Disease



Professor Julie Williams

School of Psychological Medicine, Cardiff  University