© 2015 Cardiff Scientific Society
About half a century ago, nuclear transfer experiments in frogs eggs established the principle that nearly all somatic cells have the same genome. These experiments showed that it is possible to generate multipotent embryo cells starting with nuclei from differentiated cells combined with enucleated, unfertilized eggs. Five years ago, induced pluripotency by transcription factors was discovered and has revolutionized the field of regenerative medicine. Any route by which cell replacement from adult cells is achieved depends entirely on the use of embryonic stem cells as discovered by Martin Evans in 1981. Current work in the nuclear reprogramming field aims to identify the molecules and mechanisms by which embryonic cells can be derived from adult cells. While induced pluripotency seems to involve stochastic processes, nuclear reprogramming by eggs and oocytes appears to be a deterministic process. Nuclear reprogramming has the prospect of being useful for drug testing and possibly for certain kinds of cell replacement therapy.
*Light refreshments will be available from 6.45pm
The Sir Martin Evans Lecture:
Nuclear Reprogramming by Eggs and Oocytes: a Route to Cell Replacement
Sponsored by Cardiff University*
Gurdon Institute, Cambridge University
Entrepreneur, Honorary Professor Imperial College