© 2015 Cardiff Scientific Society

Abstract


About half a century ago, nuclear transfer experiments in frogs eggs established the principle that nearly all somatic cells have the same genome. These experiments showed that it is possible to generate multipotent embryo cells starting with nuclei from differentiated cells combined with enucleated, unfertilized eggs. Five years ago, induced pluripotency by transcription factors was discovered and has revolutionized the field of regenerative medicine. Any route by which cell replacement from adult cells is achieved depends entirely on the use of embryonic stem cells as discovered by Martin Evans in 1981. Current work in the nuclear reprogramming field aims to identify the molecules and mechanisms by which embryonic cells can be derived from adult cells. While induced pluripotency seems to involve stochastic processes, nuclear reprogramming by eggs and oocytes appears to be a deterministic process. Nuclear reprogramming has the prospect of being useful for drug testing and possibly for certain kinds of cell replacement therapy.


*Light refreshments will be available from 6.45pm

The Sir Martin Evans Lecture:

Nuclear Reprogramming by Eggs and Oocytes: a  Route to Cell Replacement

Sponsored by Cardiff University*


Professor Sir John Gurdon FRS

Gurdon Institute, Cambridge University

Entrepreneur, Honorary Professor Imperial College

2nd November 2011 Large Chemistry Lecture Theatre, Cardiff University