© 2015 Cardiff Scientific Society

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Stem cells in the adult can often respond to damage or to physiological demand, but the mechanisms involved largely remain obscure. Often cells within the CNS (NSCs) receive instructions from their niche to activate cell proliferation and determine the balance between self-renewal and differentiation. Endothelial cells (ECs) of the microvascalature form part of this niche, and I will discuss how specific factors made by ECs influence regeneration from NCSs. The pituitary is involved in homeostasis, but also in controlling change in physiological processes, such as sexual maturation, pregnancy and lactation. It must therefore be able to modulate its hormonal output. Through testing situations where plasticity is known to occur, we have found that a stem cell population is mobilized to give rise to the appropriate hormone-producing cell type.

Division of Stem Cell Biology & Developmental Genetics,

 MRC National Institute for Medical Research,

 Mill Hill, London

Dr Robin Lovell-Badge FRS FMedSci

GFP expression driven by a testis-specific enhancer of Sox9 in transgenic mice

Pituispheres contain progenitors expressing SOX2 (green) and S100 protein (blue), able to differentiate into hormone-producing cells (green)

A drinks reception will be available from 6.45pm

16th October 2013

Large Chemistry Lecture Theatre
Cardiff University

The Sir Martin Evans Lecture

Stem Cell Biology